NFκB and Survivin-Mediated Radio-Adaptive Response
نویسندگان
چکیده
منابع مشابه
A survivin-associated adaptive response in radiation therapy.
Adaptive responses can be induced in cells by very low doses of ionizing radiation resulting in an enhanced resistance to much larger exposures. The inhibitor of apoptosis protein, survivin, has been implicated in many adaptive responses to cellular stress. Computerized axial tomography used in image-guided radiotherapy to position and monitor tumor response uses very low radiation doses rangin...
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Background: Radio-adaptive response and bystander effects are known phenomena occurring in cells following exposure to ionizing radiation (IR). In this study we examined possible radio-adaptation of lymphocytes following bystander effects induced by CHO-K1 cells. Materials and Methods: Whole blood and CHO-K1 cells were cultured in RPMI-1640 complete medium. Cells were separately irradiated with...
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Endothelial cells represent an important barrier between the intravascular compartment and extravascular tissues, and therefore serve as key sensors, communicators, and amplifiers of danger signals in innate immunity and inflammation. Double stranded DNA (dsDNA) released from damaged host cells during injury or introduced by pathogens during infection, has emerged as a potent danger signal. Whi...
متن کاملCFTR Is a Negative Regulator of NFκB Mediated Innate Immune Response
BACKGROUND Dysfunctional CFTR in the airways is associated with elevated levels of NFkappaB mediated IL-8 signaling leading to neutrophil chemotaxis and chronic lung inflammation in cystic fibrosis. The mechanism(s) by which CFTR mediates inflammatory signaling is under debate. METHODOLOGY/PRINCIPAL FINDINGS We tested the hypothesis that wt-CFTR down-regulates NFkappaB mediated IL-8 secretion...
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ژورنال
عنوان ژورنال: Radiation Research
سال: 2015
ISSN: 0033-7587,1938-5404
DOI: 10.1667/rr14002.1